Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism

Halpert, JR; Domanski, TL; Adali, ORHAN; Biagini, CP; Cosme, J; Dierks, EA; Johnson, EF; Jones, JP; de Montellano, PO; Philpot, RM; Sibbesen, O; Wyatt, WK; Zheng, ZP

Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism

Atıf İçin Kopyala

Halpert J., Domanski T., Adali O., Biagini C., Cosme J., Dierks E., ...Daha Fazla

DRUG METABOLISM AND DISPOSITION, cilt.26, sa.12, ss.1223-1231, 1998 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 26 Sayı: 12
Basım Tarihi: 1998
Dergi Adı: DRUG METABOLISM AND DISPOSITION
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1223-1231
Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.