Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism

Halpert J., Domanski T., Adali O., Biagini C., Cosme J., Dierks E., ...More

DRUG METABOLISM AND DISPOSITION, vol.26, no.12, pp.1223-1231, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 12
  • Publication Date: 1998
  • Journal Name: DRUG METABOLISM AND DISPOSITION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1223-1231
  • Middle East Technical University Affiliated: Yes

Abstract

This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.