Structure-function of cytochromes P450 and flavin-containing monooxygenases - Implications for drug metabolism


Halpert J., Domanski T., Adali O. , Biagini C., Cosme J., Dierks E., ...Daha Fazla

DRUG METABOLISM AND DISPOSITION, cilt.26, ss.1223-1231, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 26 Konu: 12
  • Basım Tarihi: 1998
  • Dergi Adı: DRUG METABOLISM AND DISPOSITION
  • Sayfa Sayıları: ss.1223-1231

Özet

This article is a report on a symposium held at Experimental Biology '98 in San Francisco, California. Recent developments in site-directed mutagenesis, computer-modeling, and mechanistic analysis of cytochromes P450 and flavin-containing monooxygenases are described. A unifying theme is the elaboration of general approaches for understanding and predicting the function of individual forms of these enzymes. A related goal is the production of soluble forms of mammalian cytochromes P450 for X-ray crystallography.