JOURNAL OF ORGANIC CHEMISTRY, vol.74, no.5, pp.2197-2199, 2009 (SCI-Expanded)
Article / Article
JOURNAL OF ORGANIC CHEMISTRY
Science Citation Index Expanded (SCI-EXPANDED), Scopus
Middle East Technical University Affiliated:
The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.