Catalytic Intermolecular Aldehyde-Ketone Coupling via Acyl Phosphonates


DEMİR A. G. , Esiringue I., Gollu M., Reis O.

JOURNAL OF ORGANIC CHEMISTRY, cilt.74, ss.2197-2199, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 74 Konu: 5
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1021/jo8026627
  • Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
  • Sayfa Sayıları: ss.2197-2199

Özet

The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.