Multiplication free neural network for cancer stem cell detection in H&E stained liver images

Badawi D., Akhan E., Mallah M., ÜNER A., Cetin-Atalay R., Cetin A. E.

Conference on Compressive Sensing VI - From Diverse Modalities to Big Data Analytics, California, United States Of America, 12 - 13 April 2017, vol.10211 identifier identifier

  • Publication Type: Conference Paper / Full Text
  • Volume: 10211
  • Doi Number: 10.1117/12.2262338
  • City: California
  • Country: United States Of America
  • Keywords: Cancerous stem cells, H&E staining, CD13 marker, Neural Network, Computer Vision, Energy Efficiency, CD13
  • Middle East Technical University Affiliated: Yes


Markers such as CD13 and CD133 have been used to identify Cancer Stem Cells (CSC) in various tissue images. It is highly likely that CSC nuclei appear as brown in CD13 stained liver tissue images. We observe that there is a high correlation between the ratio of brown to blue colored nuclei in CD13 images and the ratio between the dark blue to blue colored nuclei in H&E stained liver images. Therefore, we recommend that a pathologist observing many dark blue nuclei in an H&E stained tissue image may also order CD13 staining to estimate the CSC ratio. In this paper, we describe a computer vision method based on a neural network estimating the ratio of dark blue to blue colored nuclei in an H&E stained liver tissue image. The neural network structure is based on a multiplication free operator using only additions and sign operations. Experimental results are presented.