Enzymatic synthesis of benzoin in supercritical carbon dioxide

Celebi N., Yildiz N., Demir A. S., Calimli A.

JOURNAL OF SUPERCRITICAL FLUIDS, vol.41, no.3, pp.386-390, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.supflu.2006.12.007
  • Journal Name: JOURNAL OF SUPERCRITICAL FLUIDS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.386-390
  • Middle East Technical University Affiliated: Yes

Abstract

Enantioselective enzymatic hydrolysis of benzoyl-benzoin catalyzed by Candida cylindracea (CCL) lipase was carried out in SCCO2. It was found that CCL lipase enantioselectively hydrolyzed the (R)-benzoin. The enantiomeric excess of product (ee(p)) was maximized at 35 degrees C near the critical region 90 bar and obtained 61.3% at a 50% conversion. CCL did not catalyze the reaction in an atmospherical condition. (C) 2006 Elsevier B.V. All rights reserved.