Novel model selection criteria on sparse biological networks

Bulbul G. B., Purutcuoglu V., Purutcuoglu E.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY, vol.16, no.9, pp.5359-5364, 2019 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 9
  • Publication Date: 2019
  • Doi Number: 10.1007/s13762-019-02206-9
  • Journal Name: INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5359-5364
  • Keywords: Model selection criteria, Simulated gene networks, Gaussian graphical model, REGULATORY NETWORKS, MATHEMATICAL-MODEL, GRAPHICAL MODELS, LINEAR-MODELS, OPTIMIZATION, TIME, ROBUSTIFICATION, UNCERTAINTY, PREDICTION, INFERENCE
  • Middle East Technical University Affiliated: Yes

Abstract

In statistical literature, gene networks are represented by graphical models, known by their sparsity in high dimensions. In this study, we suggest novel model selection criteria, namely, ICOMP, CAIC and CAICF to apply on simulated gene networks when selecting an optimal model among alternative estimated networks' constructions. In this description, we build models with the Gaussian graphical model (GGM) and the inference of GGM is achieved via the graphical lasso method. In the assessment of our proposed model selection criteria, we compare their accuracies with other well-known criteria in this field under various dimensions and topologies of networks.