Interfacial synergy in a CoS2/Ketjen black hybrid electrode enabling electrochemical detection of sertraline hydrochloride
Analytical and Bioanalytical Chemistry, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Basım Tarihi: 2026
- Doi Numarası: 10.1007/s00216-026-06670-4
- Dergi Adı: Analytical and Bioanalytical Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Artic & Antarctic Regions, BIOSIS, Chemical Abstracts Core, Chimica, Compendex, EMBASE, MEDLINE, Academic Search Ultimate (EBSCO), Natural Science Collection (ProQuest), Biological Science Database (ProQuest), Biomedical Reference Collection: Corporate Edition (EBSCO), Health Research Premium Collection (ProQuest), Materials Science & Engineering Collection (ProQuest), Technology Collection (ProQuest)
- Anahtar Kelimeler: Cobalt disulfide, Electrochemical sensor, Environmental monitoring, Pharmaceutical contaminants, Sertraline
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
A hybrid electrode integrating cobalt disulfide (CoS2) nanosheets with high-surface-area Ketjen black (KB) was developed for the electrochemical detection of sertraline hydrochloride (SER), a widely prescribed antidepressant increasingly found as an environmental contaminant. CoS2 nanosheets synthesized hydrothermally at 180 °C exhibited well-defined crystalline features and a nanosheet morphology confirmed via detailed characterizations. The incorporation of KB provided enhanced conductivity and active interfacial sites, yielding a synergistic hybrid surface with improved electron transfer kinetics. The optimized KB + CoS2-modified screen-printed carbon electrode demonstrated a sharp oxidation peak corresponding to the two-electron, two-proton transformation of SER, achieving a limit of detection (LOD) of 0.0037 nM with a wide linear range of 1 nM–1 µM. The sensor displayed remarkable reproducibility (RSD = 1.32%) and high recovery of 108–123% and 103–110.6% in surface water and wastewater samples, respectively. This study highlights the interfacial synergy of KB and CoS2 as a promising route toward an efficient, scalable, and sustainable electrochemical platform for pharmaceutical residue monitoring.