Electrospun polyacrylonitrile nanofibrous biomaterials

Ren X., Akdag A., Zhu C., Kou L., Worley S. D., Huang T. S.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, sa.2, ss.385-390, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/jbm.a.32260
  • Dergi Adı: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.385-390
  • Anahtar Kelimeler: nanofiber, N-halamine, polyacrylonitrile, anti-microbial, bioactivity, HYDANTOIN-CONTAINING MONOMERS, POLYMERIC SURFACE MODIFIERS, ANTIMICROBIAL PROPERTIES, SILOXANE COPOLYMERS, BIOCIDAL POLYMERS, TEXTILE MATERIALS, COTTON CELLULOSE, COATINGS, STABILIZATION, QUATERNARY
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

An N-halamine precursor, 3-(5'-methyl-5'-hydantoinyl)acetanilide (1), was synthesized in our laboratory and loaded onto electrospun polyacrylonitrile fiber to prepare nanosized biocidal materials, which could be rendered antimicrobial by exposure to household bleach. Differential scanning calorimetry was used to study the thermal properties of the nanofibers with and without the N-halamine precursor and its chlorinated derivative loaded. Scanning electron microscopy demonstrated that the ultrafine fibers formed with diameters from 250 to 600 nm. Chlorinated nanofibrous mats composed of the fibers were challenged with Staphylococcus aureus (ATCC 6538) and Escherichia coli O157:H7 (ATCC 43895); they showed promising inactivation efficacies against the two bacterial species within 5 minutes of contact. Potential uses of the antimicrobial fibers include filters for industrial water and air disinfection and protective clothing. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 91A: 385-390,2009