Breath sensors for lung cancer diagnosis

Adiguzel Y., KÜLAH H.

BIOSENSORS & BIOELECTRONICS, cilt.65, ss.121-138, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 65
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.bios.2014.10.023
  • Dergi Adı: BIOSENSORS & BIOELECTRONICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.121-138
  • Anahtar Kelimeler: Breath sensor, Breath analysis, Electronic nose (e-nose), Lung cancer, Disease diagnosis, VOLATILE ORGANIC-COMPOUNDS, CELLS IN-VITRO, TERM FOLLOW-UP, EXHALED BREATH, ELECTRONIC-NOSE, OLFACTORY BIOSENSOR, ARRAY, BIOMARKERS, DISCRIMINATION, IDENTIFICATION
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

The scope of the applications of breath sensors is abundant in disease diagnosis. Lung cancer diagnosis is a well-fitting health-related application of this technology, which is of utmost importance in the health sector, because lung cancer has the highest death rate among all cancer types, and it brings a high yearly global burden. The aim of this review is first to provide a rational basis for the development of breath sensors for lung cancer diagnostics from a historical perspective, which will facilitate the transfer of the idea into the rapidly evolving sensors field. Following examples with diagnostic applications include colorimetric, composite, carbon nanotube, gold nanoparticle-based, and surface acoustic wave sensor arrays. These select sensor applications are widened by the state-of-the-art developments in the sensors field. Coping with sampling sourced artifacts and cancer staging are among the debated topics, along with the other concerns like proteomics approaches and biomimetic media utilization, feature selection for data classification, and commercialization. (C) 2014 Elsevier B.V. All rights reserved.