Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status

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Durmaz I., Guven E. B., Ersahin T., ÖZTÜRK M., Calis I., Cetin-Atalay R.

PHYTOMEDICINE, vol.23, no.1, pp.42-51, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.1016/j.phymed.2015.11.012
  • Journal Name: PHYTOMEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.42-51
  • Keywords: Lanatoside C, Oxidative stress, ERK, Akt, PTEN, Hepatocelltilar carcinoma, HEPATOCELLULAR-CARCINOMA, GLYCOSIDES, APOPTOSIS, AUTOPHAGY
  • Middle East Technical University Affiliated: Yes

Abstract

Background: Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting this pathway present good therapeutic strategies for liver cancer.