Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status


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Durmaz I., Guven E. B., Ersahin T., ÖZTÜRK M., Calis I., Cetin-Atalay R.

PHYTOMEDICINE, cilt.23, sa.1, ss.42-51, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.phymed.2015.11.012
  • Dergi Adı: PHYTOMEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.42-51
  • Anahtar Kelimeler: Lanatoside C, Oxidative stress, ERK, Akt, PTEN, Hepatocelltilar carcinoma, HEPATOCELLULAR-CARCINOMA, GLYCOSIDES, APOPTOSIS, AUTOPHAGY
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background: Hepatocellular carcinoma is the second deadliest cancer with limited treatment options. Loss of PTEN causes the P13K/Akt pathway to be hyperactive which contributes to cell survival and resistance to therapeutics in various cancers, including the liver cancer. Hence molecules targeting this pathway present good therapeutic strategies for liver cancer.