Methanol feeding strategy design enhances recombinant human growth hormone production by Pichia pastoris

Gunes H., BOY E., Ata O., Zerze G. H., ÇALIK P., Ozdamar T. H.

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, cilt.91, sa.3, ss.664-671, 2016 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 91 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1002/jctb.4619
  • Dergi Adı: JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.664-671
  • Anahtar Kelimeler: Biochemical engineering, Bioprocesses, Biotechnology, Bioreactors, Fermentation, FED-BATCH, PROTEIN-PRODUCTION, CARBON-SOURCES, FERMENTATION, EXPRESSION, SORBITOL, GLUCOSE, METABOLISM, MANNITOL, PROMOTER
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

BACKGROUND: The effects of designed methanol and co-substrate feeding strategies on fed-batch recombinant human growth hormone (rhGH) production by Pichia pastoris hGH-Mut(+) were investigated.