Inorganic compounds have dual effect on recombinant protein production: influence of anions and cations on serine alkaline protease production

Calik P., Bilir E., Ozcelik I., Calik G., Ozdamar T.

JOURNAL OF APPLIED MICROBIOLOGY, vol.96, no.1, pp.194-200, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 96 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1046/j.1365-2672.2003.02141.x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.194-200
  • Keywords: acetate, Bacillus, chloride, fermentation, inorganic compounds, magnesium, manganese, medium, serine alkaline protease, subC, sulphate, BACILLUS-LICHENIFORMIS, METABOLIC REGULATIONS, PH CONDITIONS, FERMENTATION, CULTURE, ACID
  • Middle East Technical University Affiliated: Yes


Aims: Investigation of concerted effects of cations, i.e. Mg2+ and Mn2+, in combination with their anions, i.e. sulphate, chloride and acetate (Ac), on the physiology of Bacillus licheniformis carrying pHV1431::subC to improve the fermentation medium for serine alkaline protease (SAP) production, whereupon, determination of the acid that can be used in pH control.