WLS Expression in ER+ Breast Cancers


Erson Bensan A. E. , Çırçır Hatıl A.

International Congress of the Mol. Biology Association of Turkey, İzmir, Türkiye, 5 - 08 Eylül 2018, ss.72

  • Basıldığı Şehir: İzmir
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.72

Özet

Wnt signaling is a developmentally important signaling pathway and is mutated and/or deregulated in various cancer types. We identified a retromer protein SNX3 that regulates recycling of WLS (Wntless) receptor that has a role in WNT ligand secretion. Secreted WNT ligands can then bind to Frizzled family receptors on that same cell or neighboring cells to activate the nuclear accumulation of β-catenin in the nucleus. We identified SNX3 in a transcriptomic screen where shorter 3’UTR isoforms were over represented in breast cancers. Given that SNX3 has been implicated in endocytic recycling of WLS, we hypothesized SNX3 to be a potential cancer related gene in breast cancers through regulating WLS. Therefore, here, we aimed to study SNX3 in ER+ breast cancers that are known not to be heavily dependent on Wnt signaling. We present evidence on SNX3 silencing in ER+ breast cancers and how WLS and Wnt signaling cascades are affected. Further studies will clarify the significance of SNX3/WLS connection and Wnt signaling in ER+ breast cancers