Balanced Intersystem Crossing in Iodinated Silicon-Fluoresceins Allows New Class of Red Shifted Theranostic Agents.

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Cetin S., Elmazoglu Z., Karaman O., Gunduz H., Günbaş E. G., Kolemen S.

ACS medicinal chemistry letters, cilt.12, ss.752-757, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1021/acsmedchemlett.1c00018
  • Dergi Adı: ACS medicinal chemistry letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Chemical Abstracts Core, EMBASE
  • Sayfa Sayıları: ss.752-757
  • Anahtar Kelimeler: Photodynamic therapy, cancer, theranostic, silicon-fluorescein, fluorescence imaging, SINGLET OXYGEN GENERATION, SUBSTITUTED XANTHENE DYES, PHOTODYNAMIC THERAPY, BODIPY DYES, CANCER, PHOTOSENSITIZERS, PROBES
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

© 2021 The Authors. Published by American Chemical Society.Iodination of the silicon-fluorescein core revealed a new class of highly cytotoxic, red-shifted and water-soluble photosensitizer (SF-I) which is also fairly emissive to serve as a theranostic agent. Singlet oxygen generation capacity of SF-I was evaluated chemically, and up to 45% singlet oxygen quantum yield was reported in aqueous solutions. SF-I was further tested in triple negative breast (MDA MB-231) and colon (HCT-116) cancer cell lines, which are known to have limited chemotherapy options as well as very poor prognosis. SF-I induced efficient singlet oxygen generation and consequent photocytotoxicity in both cell lines upon light irradiation with a negligible dark toxicity while allowing cell imaging at the same time. SF-I marks the first ever example of a silicon xanthene-based photosensitizer and holds a lot of promise as a small-molecule-based theranostic scaffold.