Vancomycin containing PLLA/beta-TCP controls experimental osteomyelitis in vivo


Kankilic B., BİLGİÇ E., KORKUSUZ P., KORKUSUZ F.

JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH, vol.9, 2014 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9
  • Publication Date: 2014
  • Doi Number: 10.1186/s13018-014-0114-3
  • Title of Journal : JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
  • Keywords: Bone, Osteomyelitis, Drug delivery, Rat, Vancomycin, PLLA, beta-TCP, MRSA, Infection, TRICALCIUM PHOSPHATE COMPOSITES, POLY-EPSILON-CAPROLACTONE, IMPLANTS, RELEASE, MODEL, VITRO, INFECTIONS, KINETICS, DELIVERY, RATS

Abstract

Background: Implant-related osteomyelitis (IRO) is recently controlled with local antibiotic delivery systems to overcome conventional therapy disadvantages. In vivo evaluation of such systems is however too little.