A critical note on the definition of phase-amplitude cross-frequency coupling

ÖZKURT T. E., Schnitzler A.

JOURNAL OF NEUROSCIENCE METHODS, vol.201, no.2, pp.438-443, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 201 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.jneumeth.2011.08.014
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.438-443
  • Keywords: Cross-frequency coupling, Parkinson's disease, Phase-amplitude coupling, Oscillations, Local field potentials, Synchronization, NEURONAL OSCILLATIONS, SUBTHALAMIC NUCLEUS, PARKINSONS-DISEASE, GAMMA-POWER, TASK, MECHANISM
  • Middle East Technical University Affiliated: No


Recent studies have observed the ubiquity of phase-amplitude coupling (PAC) phenomenon in human and animal brain recordings. While various methods were performed to quantify it, a rigorous analytical definition of PAC is lacking. This paper yields an analytical definition and accordingly offers theoretical insights into some of the current methods. A direct PAC estimator based on the given definition is presented and shown theoretically to be superior to some of the previous methods such as general linear model (GLM) estimator. It is also shown that the proposed PAC estimator is equivalent to GLM estimator when a constant term is removed from its formulation. The validity of the derivations is demonstrated with simulated data of varying noise levels and local field potentials recorded from the subthalamic nucleus of a Parkinson's disease patient. (C) 2011 Elsevier B.V. All rights reserved.