A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering

Alissa Alam H., Dalgıç A. D., Tezcaner A., Özen C., Keskin D.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.69, no.6, pp.339-350, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 69 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.1080/00914037.2019.1581198
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Page Numbers: pp.339-350
  • Keywords: Wet coaxial electrospinning, poloxamer 188, dual release, bone scaffold, beta-lactoglobulin, vitamin K2, DRUG-DELIVERY, SILK FIBROIN, NANOFIBROUS SCAFFOLD, POLYMER NANOFIBERS, STEM-CELLS, IN-VITRO, HYDROXYAPATITE, RELEASE, FIBERS, DIFFERENTIATION
  • Middle East Technical University Affiliated: Yes

Abstract

Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in terms of morphology, chemistry, mechanical property, water retention, weight loss, porosity and release properties. Coaxial fibers supported duel release of model hydrophilic protein (Beta-lactoglobulin) and hydrophobic agent vitamin K2. Novel PCL/P-188(Shell):Gelatin/P-188(Core) coaxial scaffold had superior stability, average weight loss, no swelling behavior, controlled release of Beta-lactoglobulin and vitamin K2, enhanced Saos-2 cell viability and ALP activity and could be a good candidate as a bone tissue scaffold.