A comparative study of monoaxial and coaxial PCL/gelatin/Poloxamer 188 scaffolds for bone tissue engineering

Alissa Alam H., Dalgıç A. D., Tezcaner A., Özen C., Keskin D.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, cilt.69, sa.6, ss.339-350, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/00914037.2019.1581198
  • Dergi Adı: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chimica, Compendex, INSPEC
  • Sayfa Sayıları: ss.339-350
  • Anahtar Kelimeler: Wet coaxial electrospinning, poloxamer 188, dual release, bone scaffold, beta-lactoglobulin, vitamin K2, DRUG-DELIVERY, SILK FIBROIN, NANOFIBROUS SCAFFOLD, POLYMER NANOFIBERS, STEM-CELLS, IN-VITRO, HYDROXYAPATITE, RELEASE, FIBERS, DIFFERENTIATION
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Structure of fibrous scaffolds varies depending on the electrospinning method and parameters which will define cell fate. In this study, monoaxial and coaxial electrospun PCL/gelatin/P-188 scaffolds were characterized in terms of morphology, chemistry, mechanical property, water retention, weight loss, porosity and release properties. Coaxial fibers supported duel release of model hydrophilic protein (Beta-lactoglobulin) and hydrophobic agent vitamin K2. Novel PCL/P-188(Shell):Gelatin/P-188(Core) coaxial scaffold had superior stability, average weight loss, no swelling behavior, controlled release of Beta-lactoglobulin and vitamin K2, enhanced Saos-2 cell viability and ALP activity and could be a good candidate as a bone tissue scaffold.