Nonlinear effects in proline-thiourea host-guest complex catalyzed aldol reactions in nonpolar solvents


DEMİR A. G. , Eymur S.

TETRAHEDRON-ASYMMETRY, cilt.21, sa.4, ss.405-409, 2010 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Konu: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.tetasy.2010.02.009
  • Dergi Adı: TETRAHEDRON-ASYMMETRY
  • Sayfa Sayıları: ss.405-409

Özet

An aldol reaction catalyzed by a proline-thiourea host-guest complex in a nonpolar solvent shows excellent nonlinear effects. This proline-thiourea system has the ability to form a hydrogen-bonding network. The enantiomeric excess of proline in a solution can be significantly enhanced by its incorporation with a urea molecule into its solid racemate. This suggests a general and facile route to homochirality, which may be involved in the origin of chirality on earth. (C) 2010 Elsevier Ltd. All rights reserved.