In this study, a bibliometric analysis of hydroxyapatite (HA) and scaffold research using the online version of Science Citation Index (SCI) databases of the Thomson Reuters’ Web of Science Core Collection from 1991 to 2019 was performed. The stages of the study included the analysis of the author’s keywords, annual scientific production, and contributions of countries, institutions, and publication sources. Analysis of 8752 publications showed an increase in using HA-based scaffolds as a promising strategy to treat tissue defects. Global trend inclined toward the application of additive manufacturing (AM) to fabricate scaffolds. AM techniques such as Stereolithography, direct inkjet 3D printing, selective laser sintering, and fused deposition modeling seem to have more applications in production of ceramic-based scaffolds and will see further advancement in the coming years. Among 90 countries, the USA and China were countries that provided the highest number of publications during the investigated period. The most productive three institutions in this research area were located in China. Throughout the past 29 years, Journal of Biomedical Materials Research Part A, Materials Science, and Engineering: C, Journal of Materials Science: Materials in Medicine, Acta Biomaterialia and Biomaterials have the highest number of publications on HA and scaffold research.