The investigation of brain growth retardation in rat fetus
BIOCHEMICAL ARCHIVES, vol.15, no.1, pp.69-74, 1999 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 15 Issue: 1
- Publication Date: 1999
- Journal Name: BIOCHEMICAL ARCHIVES
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.69-74
- Middle East Technical University Affiliated: No
Abstract
We have investigated the activation of the mitogen-activated protein kinases ERK1 and ERK2 in fetal rat brain following induction of ischemia. This treatment rapidly increases the phosphorylation of MAP kinase levels after induction appears to reach a maximum at 2 hrs recirculation time. The ischemic effect on fetal brain might lead to mitogen-activated protein kinase activation and subsequent protein phosphorylation.