A bis-Lewis basic 2-aminoDMAP/prolinamide organocatalyst for application to the enantioselective synthesis of Warfarin and derivatives
TETRAHEDRON-ASYMMETRY, vol.27, pp.384-388, 2016 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27
- Publication Date: 2016
- Doi Number: 10.1016/j.tetasy.2016.04.001
- Journal Name: TETRAHEDRON-ASYMMETRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.384-388
- Middle East Technical University Affiliated: Yes
Abstract
A new chiral sec-amine/amidine-base hybrid catalyst, 2-aminoDMAP/prolinamide, is reported, which is able to catalyze conjugate addition of 4-hydroxycoumarin and various benzylideneacetones, a reaction that directly gives anticoagulant Warfarin and its analogues, with good yields (70-87%) and enantioselectivities (58-72%). (C) 2016 Elsevier Ltd. All rights reserved.