Nuclear Magnetic Resonance (NMR) systems with inhomogenous main magnetic fields have been satisfactorily used to explore material properties. So that, imaging of biological tissues using Magnetic Resonance Imaging (MRI) systems with inhomogenous main magnetic fields could be explored. In this work, magnetic resonance (MR) signal deviation due to inhomogeneity in the main magnetic field of a MRI system is investigated. This analysis gives the understanding of the effect of inhomogeneity in magnetic field to signal decay time, energy and peak. Using these parameters, suitability of specific MRI hardware designed for inhomogeneous magnetic field can be analyzed. In other words, using proposed analysis, the inhomogeneity tolerance of a specific hardware can be found. Meanwhile, given the inhomogeneity distribution, the hardware design parameters can be selected accordingly to acquire MR signal.