Dyslipidemia and oxidative stress in patients of psoriasis

Gupta M., Chari S., Borkar M., Chandankhede M.

BIOMEDICAL RESEARCH-INDIA, vol.22, no.2, pp.221-224, 2011 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2011
  • Journal Name: BIOMEDICAL RESEARCH-INDIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.221-224
  • Keywords: Psoriasis, oxidative stress, lipid profile, antioxidant enzymes, LIPID PROFILE, ANTIOXIDANTS, BLOOD, RISK, OXIDANTS, SELENIUM, MODERATE, SKIN
  • Middle East Technical University Affiliated: No

Abstract

Psoriasis is a common chronic inflammatory skin disease with an unknown etiology. The aim of this research was to determine the lipid profile and levels of lipid peroxidation as malondialdehyde (MDA), antioxidant enzymes glutathione peroxidase (GPx) and superoxide dismutase (SOD) in patients with psoriasis. The levels of lipid profile were significantly altered in the patient group. Levels of MDA were significantly increased (p<0.001) where as the GPx and SOD were significantly decreased (p<0.001) in patients with psoriasis. These results provide some evidence regarding the role of increased reactive oxygen species and decreased antioxidant activity in psoriasis.