Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water

Demir A., Akhmedov I., Sesenoglu O.

TURKISH JOURNAL OF CHEMISTRY, cilt.23, sa.2, ss.123-126, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 2
  • Basım Tarihi: 1999
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.123-126
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH4 in the presence of NiCl2 or MoO3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.