Transition metal compound mediated reduction of alpha-amino acids to 1,2-amino alcohols with NaBH4 in water


Demir A. , Akhmedov I., Sesenoglu O.

TURKISH JOURNAL OF CHEMISTRY, vol.23, no.2, pp.123-126, 1999 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 2
  • Publication Date: 1999
  • Title of Journal : TURKISH JOURNAL OF CHEMISTRY
  • Page Numbers: pp.123-126

Abstract

A new efficient and cost-effective method for the preparation of 1,2-amino alcohols is described. The reactions of amino acids with NaBH4 in the presence of NiCl2 or MoO3 in water give 1,2-amino alcohols in high yield. When optically pure amino acids were used, optically pure 1,2-amino alcohols were obtained.