Reaction of 4-methoxy-4-(1-methylethenyl)-2-cyclobutenone derivatives with 2-lithiopropene and alpha-lithiostyrene: synthesis of eight-membered ring carbocycles

Zora M. , Koyuncu I., Yucel B.

TETRAHEDRON LETTERS, vol.41, no.36, pp.7111-7114, 2000 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 36
  • Publication Date: 2000
  • Doi Number: 10.1016/s0040-4039(00)01173-4
  • Title of Journal : TETRAHEDRON LETTERS
  • Page Numbers: pp.7111-7114


2-Alkyl- or phenyl-substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones react with 2-lithiopropene or alpha-lithiostyrene to produce 4-methoxy-2,4-cyclooctadienones in moderate yield, accompanied by varying amounts of 4-methoxy-4-(1-methylethenyl)-2-cyclohexenones. The reaction is general for 2-alkyl substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones. (C) 2000 Elsevier Science Ltd. All rights reserved.