Biochimica et Biophysica Acta - General Subjects, vol.1864, 2020 (SCI-Expanded)
Article / Article
Biochimica et Biophysica Acta - General Subjects
Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
Doxorubicin, Anthracycline, G-quadruplex, DNA, Cancer, VEGF, INDUCED APOPTOSIS, HUMAN TELOMERASE, PROMOTER REGION, SMALL MOLECULES, DNA, DISCOVERY, SEQUENCE, CARDIOTOXICITY, ADRIAMYCIN, INSIGHTS
Middle East Technical University Affiliated:
Background: Vascular endothelial growth factor (VEGF), is upregulated in tumor cells and thus became a potential therapeutic target for anti-cancer drugs. Recent reports suggested the use of Doxorubicin (Dox) with VEGF-targeting siRNAs for an enhanced decrease in VEGF expression. Besides, VEGF-B gene therapy was found to suppress the cardiotoxicity effects of Dox. On the other hand, even though Dox is a commonly used anti-cancer agent, its mechanism of actions isn't completely mapped out. Herein, the interactions between a G4 structure formed by the VEGF promoter region Pu-22 and Dox were investigated.