One-pot synthesis of N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives

Tanyeli C., Akhmedov I., Yazicioglu E.

TETRAHEDRON LETTERS, cilt.45, sa.52, ss.9627-9629, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 52
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.tetlet.2004.10.145
  • Dergi Adı: TETRAHEDRON LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9627-9629
  • Anahtar Kelimeler: 4,5,6,7-tetrahydroindoles, enamines, EFFICIENT, INDOLE, RING, INHIBITORS, REDUCTION, PYRROLE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

We describe the preliminary results of one-pot syntheses of various N-substituted 2-methyl-4,5,6,7-tetrahydroindole derivatives from 2-(2-bromoailyl)cyclohexanone and the corresponding primary amines in good yields. Aliphatic amines were directly converted to tetrahydroindoles, whereas aromatic amines needed an extra base treatment step to complete the transformation. (C) 2004 Elsevier Ltd. All rights reserved.