The following study is a framework developed for further research purposes and school evaluation. This is why it has a different structure and differs from empirical research papers. This study aims to develop a framework to evaluate schools’ STEM readiness as a whole. STEM education aims to educate individuals and society towards an integrated education system that fosters economic and technological development for having a competitive economy. However, there is little emphasis and information in the curriculum about how and what will be used in the STEM implementation. Except the name of the STEM there is little support about it in the official documents. In this sense, our purpose is to develop a framework for educational institutions to evaluate their STEM readiness with respect to teacher, student, and institutional STEM readiness. The framework developed consists of two main parts. First, it aims to evaluate institution’s STEM readiness with respect to four domains. Domain 1 is School Vision and Structures for successful STEM education. This domain aims to evaluate school’s STEM culture, vision, budget and program about STEM education. Domain 2 is Curriculum, Instruction and Assessment. This domain is targeting the evaluation of curriculum, instruction to see if includes STEM education, and STEM related teaching strategies. Domain 3 is Strategic Partnership. Domain 4 is College and Career Readiness. Second, evaluation of students’ STEM readiness through quantitative instruments is our choice for a complete STEM readiness evaluation. For this purpose, a questionnaire measuring students’ career interests in STEM fields is used. Since an educational institution is not complete without its’ students’ involvement in such measures, we included their readiness as well. To sum up, this framework aiming to evaluate schools’ STEM readiness can be a good guide for whom prepare their institutions STEM integration.