New chiral synthon from the PLE catalyzed enantiomeric separation of 6-acetoxy-3-methylcyclohex-2-en-1-one

Tanyeli C., Demir A., Dikici E.

TETRAHEDRON-ASYMMETRY, vol.7, no.8, pp.2399-2402, 1996 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 8
  • Publication Date: 1996
  • Doi Number: 10.1016/0957-4166(96)00296-0
  • Journal Name: TETRAHEDRON-ASYMMETRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Page Numbers: pp.2399-2402
  • Middle East Technical University Affiliated: Yes

Abstract

(+/-)-6-Acetoxy-3-methylcyclohex-2-en-1-one was resolved by PLE catalyzed hydrolysis to afford (+)-6-hydroxy-3-methylcyclohex-2-en-1-one in >95% e.e. (+)-6-Hydroxy-3-methylcyclohex-2-en-1-one was transformed to its (S)-O-acetyllactyl ester derivative to determine the e.e. %. Copyright (C) 1996 Elsevier Science Ltd