Synthesis of Furo[2,3-d]pyridazin-4(5H)-one and Its N(5)-Substituted Derivatives


Karahan E., Koza G., BALCI M.

HELVETICA CHIMICA ACTA, cilt.97, sa.11, ss.1487-1496, 2014 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 97 Konu: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/hlca.201400042
  • Dergi Adı: HELVETICA CHIMICA ACTA
  • Sayfa Sayıları: ss.1487-1496

Özet

We report the efficient preparation of furo[2,3-d] pyridazin-4(5H)-one and its N-substituted derivatives starting from methyl 2-methylfuran-3-carboxylate. The Me group was converted to the aldehyde group, which was then condensed with hydrazine derivatives. Then, the ester functionalities were hydrolyzed to the corresponding acids, followed by treatment with SOCl2 to give N-substituted furopyridazinone derivatives.