Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion
CURRENT NEUROVASCULAR RESEARCH, cilt.8, sa.3, ss.190-199, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 8 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.2174/156720211796558087
- Dergi Adı: CURRENT NEUROVASCULAR RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.190-199
- Anahtar Kelimeler: Chronic cerebral hypoperfusion, S100, synaptophysin, spatial learning, ISCHEMIC BRAIN-INJURY, WHITE-MATTER DAMAGE, PPAR-GAMMA, OXIDATIVE STRESS, COGNITIVE IMPAIRMENT, MEMORY IMPAIRMENT, RAT MODEL, ALZHEIMERS-DISEASE, NEURONAL DAMAGE, MOUSE MODEL
- Orta Doğu Teknik Üniversitesi Adresli: Evet
Özet
Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one week before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique.