Asymmetric benzoin reaction catalyzed by benzoylformate decarboxylase

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Demir A., Dunnwald T., Iding H., Pohl M., Muller M.

TETRAHEDRON-ASYMMETRY, vol.10, no.24, pp.4769-4774, 1999 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 10 Issue: 24
• Publication Date: 1999
• Doi Number: 10.1016/s0957-4166(99)00516-9
• Journal Name: TETRAHEDRON-ASYMMETRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.4769-4774
• Middle East Technical University Affiliated: Yes

Abstract

Aromatic aldehydes are converted into benzoins by benzoylformate decarboxylase catalyzed C-C bond formation. The reaction affords (R)-benzoins with high enantiomeric excess and in good chemical yields. A broad range of aromatic aldehydes can be used as substrates in aqueous buffer or buffer/DMSO-solutions. (C) 2000 Elsevier Science Ltd. All rights reserved.