Asymmetric benzoin reaction catalyzed by benzoylformate decarboxylase

Demir A., Dunnwald T., Iding H., Pohl M., Muller M.

TETRAHEDRON-ASYMMETRY, vol.10, no.24, pp.4769-4774, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 24
  • Publication Date: 1999
  • Doi Number: 10.1016/s0957-4166(99)00516-9
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4769-4774
  • Middle East Technical University Affiliated: Yes


Aromatic aldehydes are converted into benzoins by benzoylformate decarboxylase catalyzed C-C bond formation. The reaction affords (R)-benzoins with high enantiomeric excess and in good chemical yields. A broad range of aromatic aldehydes can be used as substrates in aqueous buffer or buffer/DMSO-solutions. (C) 2000 Elsevier Science Ltd. All rights reserved.