Computational study of scattering from healthy and diseased red blood cells

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Ergul O., Arslan-Ergul A., Gurel L.

JOURNAL OF BIOMEDICAL OPTICS, cilt.15, sa.4, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1117/1.3467493
  • Dergi Adı: JOURNAL OF BIOMEDICAL OPTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: red blood cell, electromagnetic scattering, surface formulations, multilevel fast multipole algorithm, FIELD INTEGRAL-EQUATION, LIGHT-SCATTERING, ELECTROMAGNETIC SCATTERING, FORMULATIONS, ELLIPSOIDS, ANEMIA
  • Orta Doğu Teknik Üniversitesi Adresli: Hayır

Özet

We present a comparative study of scattering from healthy red blood cells (RBCs) and diseased RBCs with deformed shapes. Scattering problems involving three-dimensional RBCs are formulated accurately with the electric and magnetic current combined- field integral equation and solved efficiently by the multilevel fast multipole algorithm. We compare scattering cross section values obtained for different RBC shapes and different orientations. In this way, we determine strict guidelines to distinguish deformed RBCs from healthy RBCs and to diagnose various diseases using scattering cross section values. The results may be useful for designing new and improved flow cytometry procedures. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3467493]