Imaging of liposomes by scanning tunneling microscopy

Zareie M., Borucu A., Ozden M., Hasirci V., Piskin E.

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND IMMOBILIZATION BIOTECHNOLOGY, vol.24, no.5, pp.525-531, 1996 (SCI-Expanded) identifier identifier identifier


In this study, unilamellar and multilamellar liposomes consisting of dipalmitoylphosphatidylcholine, cholesterol and dicetylphosphate were prepared. Scanning tunneling microscopy images of these liposomes on highly oriented pyrolytic graphite surfaces were obtained. It was observed that scanning tunnelling microscopy can be succesfully used for high-resolution, three-dimensional structure analysis of liposomes under very mild conditions.