Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens

Kavruk M., ÇELİKBIÇAK Ö., Ozalp V. C. , Borsa B. A. , Hernandez F. J. , BAYRAMOĞLU G., ...More

CHEMICAL COMMUNICATIONS, vol.51, no.40, pp.8492-8495, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 40
  • Publication Date: 2015
  • Doi Number: 10.1039/c5cc01869b
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.8492-8495


In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.