Antibiotic loaded nanocapsules functionalized with aptamer gates for targeted destruction of pathogens


Kavruk M., ÇELİKBIÇAK Ö., Ozalp V. C. , Borsa B. A. , Hernandez F. J. , BAYRAMOĞLU G., ...Daha Fazla

CHEMICAL COMMUNICATIONS, cilt.51, ss.8492-8495, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 51 Konu: 40
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1039/c5cc01869b
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Sayfa Sayıları: ss.8492-8495

Özet

In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.