Non-Precious Metals Catalyze Formal [4+2] Cycloaddition Reactions of 1,2-Diazines and Siloxyalkynes under Ambient Conditions
ORGANIC LETTERS, cilt.16, sa.12, ss.3236-3239, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 16 Sayı: 12
- Basım Tarihi: 2014
- Doi Numarası: 10.1021/ol501254h
- Dergi Adı: ORGANIC LETTERS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC), Current Chemical Reactions (CCR)
- Sayfa Sayıları: ss.3236-3239
- Orta Doğu Teknik Üniversitesi Adresli: Hayır
Özet
Copper(I) and nickel(0) complexes catalyze the formal [4 + 2] cycloaddition reactions of 1,2-diazines and siloxyalkynes, a reaction hitherto best catalyzed by silver salts. These catalysts based on earth abundant metals are not only competent, but the copper catalyst, in particular, promotes cycloadditions of pyrido[2,3-d]pyridazine and pyrido[3,4-d]pyridazine, enabling a new synthesis of quinoline and isoquinoline derivatives, as well as the formal [2 + 2] cycloaddition reaction of cyclohexenone with a siloxyalkyne.