© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0) Peer-review under responsibility of IWPDF 2021 Chair, Tuncay YalçinkayaDifferent manufacturing processes such as flow forming, rolling, wire drawing and additive manufacturing induce anisotropic grain structure and texture evolution at the micro scale, which results in macroscopic anisotropic plastic behavior. Among these microstructures, development of columnar grain structure is quite common especially in additively manufactured metallic materials. A systematic micromechanical analysis is necessary to evaluate the influence of both grain morphology and texture (orientation alignment) on the mechanical response of the metallic alloys produced through such innovative techniques. In this context, the objective of the present study is to investigate qualitatively the influence of the columnar grain morphology and the orientation alignment observed in additively manufactured alloys through crystal plasticity finite element (CPFEM) simulations in representative volume elements (RVEs). Different RVEs are generated through Voronoi tessellation and subjected to uniaxial tensile loading in different directions. A detailed analysis is conducted to evaluate the influence of grain structure and orientation alignment on the plastic behavior of the material through homogenization for different microstructures.