In vitro susceptibility testing methods for caspofungin against Aspergillus and Fusarium isolates


Arikan S., Lozano-Chiu M., Paetznick V., Rex J.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol.45, no.1, pp.327-330, 2001 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2001
  • Doi Number: 10.1128/aac.45.1.327-330.2001
  • Journal Name: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.327-330

Abstract

We investigated the relevance of prominent reduction in turbidity macroscopically (MIC) and formation of aberrant hyphal tips microscopically (minimum effective concentration; MEC) in measuring the in vitro activity of caspofungin against Aspergillus and Fusarium. Caspofungin generated low MICs and MECs against Aspergillus, but not for Fusarium. While MICs increased inconsistently when the incubation time was prolonged, MEC appeared as a stable and potentially relevant endpoint in testing in vitro caspofungin activity.