Biocompatible Janus microparticle synthesis in a microfluidic device

Saqib M., TUFAN Y., Orsel Z. C., ERCAN B., Erdem E. Y.

Biomedical Microdevices, cilt.26, sa.3, 2024 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1007/s10544-024-00711-4
  • Dergi Adı: Biomedical Microdevices
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CINAHL, Compendex, EMBASE, INSPEC, MEDLINE
  • Anahtar Kelimeler: Biocompatible particles, Droplet based flow, Janus particles, Microfluidics, Microreactors
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Janus particles are popular in recent years due to their anisotropic physical and chemical properties. Even though there are several established synthesis methods for Janus particles, microfluidics-based methods are convenient and reliable due to low reagent consumption, monodispersity of the resultant particles and efficient control over reaction conditions. In this work a simple droplet-based microfluidic technique is utilized to synthesize magnetically anisotropic TiO2-Fe2O3 Janus microparticles. Two droplets containing reagents for Janus particle were merged by using an asymmetric device such that the resulting droplet contained the constituents within its two hemispheres distinct from each other. The synthesized Janus particles were observed under the optical microscope and the scanning electron microscope. Moreover, a detailed in vitro characterization of these particles was completed, and it was shown that these particles have a potential use for biomedical applications.