Early osteoblastic activity on TiO(2)thin films decorated with flower-like hierarchical Au structures

Kalantzis S., Veziroglu S., Kohlhaas T., Floerke C., Mishra Y. K. , Wiltfang J., ...More

RSC ADVANCES, vol.10, no.48, pp.28935-28940, 2020 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 48
  • Publication Date: 2020
  • Doi Number: 10.1039/d0ra05141a
  • Journal Name: RSC ADVANCES
  • Journal Indexes: Science Citation Index Expanded, Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, Compendex, Metadex, Directory of Open Access Journals
  • Page Numbers: pp.28935-28940


Titanium alloys are the most commonly used dental and orthopedic implant materials due to their proven biocompatibility and mechanical properties. The native oxide layer (TiO(2)layer) formed on such Ti-based implants acts as the self-protecting layer against possible ion release. Increasing the oxide layer thickness further on such TiO(2)implants even opens the triggering of the osseointegration process if the oxide layer is having a certain degree of roughness, preferably higher. This work reports a novel photocatalytic patterning of sputter deposited TiO(2)layers with flower-like Au structures to enhance the early osteoblastic activity. The prepared hierarchical Au structures, composed of micro- and nanoscale features on the top, lead to improved number of filopodia formation. This suggest that proposed Au-TiO(2)surface may foster the cell attachment and as well as cell proliferation.