© 2020 Atlas of Genetics and Cytogenetics in Oncology and Haematology.Sorting Nexin 3 (SNX3) gene maps to chromosome 6, minus strand and has 4 exons and 3 introns. There are 3 alternatively spliced isoforms (transcripts). SNX3 is a member of the sorting nexin family. Members of this family generally have BAR domains and phosphoinositide binding regions called the phox (PX) domain, and are involved in intracellular trafficking. Unlike other sorting nexins, SNX3 does not contain a BAR domain. SNX3 protein interacts with phosphatidylinositol-3-phosphates, and is involved in protein trafficking through its role in the retromer complex.