Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings

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Gungor B., Yagci F. C., GÜRSEL İ., GÜRSEL M.

ONCOIMMUNOLOGY, cilt.3, sa.7, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 3 Sayı: 7
  • Basım Tarihi: 2014
  • Doi Numarası: 10.4161/21624011.2014.950166
  • Dergi Adı: ONCOIMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon alpha (IFN alpha) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.