Production and biological properties of nano porous glass microparticles for anticancer drug carrier

Ertuş E. B., Gulbahce-Mutlu E., Alpa S., ÖZTÜRK A.

Journal of Applied Pharmaceutical Science, vol.14, no.9, pp.120-127, 2024 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 9
  • Publication Date: 2024
  • Doi Number: 10.7324/japs.2024.168308
  • Journal Name: Journal of Applied Pharmaceutical Science
  • Journal Indexes: Scopus, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.120-127
  • Keywords: 5FU, breast cancer, drug release, MCF7, Porous glass
  • Middle East Technical University Affiliated: Yes

Abstract

Nanoporous glass (NPG) microparticles were produced by conventional melt-quenching followed by acid-alkali leaching to get material for anticancer drug carriers. NPG exhibited a positive zeta potential of 34 mV after [3-(2-aminoethylamino) propyl] trimethoxysilane treatment. The specific surface area and the total pore volume of NPG were 47.3 m2/g and 0.692 cm3/g, respectively. The 5-Fluorouracil (5FU) loading capacity of NPG was measured as 18.2 ± 0.2 mg5FU/gNPG. The drug release rate was monitored for 120 hours. To evaluate the cytotoxic effects of NPG on both MCF-7 breast cancer cells and MCF-12A, an immortalized cell line, the study employed the 2, 3-bis [2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium5-carboxanilide inner salt (XTT) assay. The XTT results revealed that NPG showed a time and concentration-dependent cytotoxic effect. It is anticipated that NPG is a safe and effective material for drug delivery systems for in vitro and a promising alternative material for in vivo applications.