Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population

Demirdogen B. C., Demirkaya S., Turkanoglu A., Bek S., Arinc E., ADALI O.

CELL BIOCHEMISTRY AND FUNCTION, cilt.27, sa.8, ss.558-567, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 8
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1002/cbf.1607
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.558-567
  • Anahtar Kelimeler: genotype, paraoxonase, PON1, polymorphism, stroke, HUMAN-SERUM PARAOXONASE, DENSITY-LIPOPROTEIN OXIDATION, INTIMA-MEDIA THICKNESS, ARYLESTERASE, PROMOTER, PROTEIN, ASSOCIATION, CHOLESTEROL, HYDROLYSIS, PHENOTYPE
  • Orta Doğu Teknik Üniversitesi Adresli: Evet

Özet

Background Paraoxonase 1 (PON1) is protective against the development of atherosclerosis. a risk factor for ischemic stroke. PON1 gene has one promoter region (-107T/C) and two coding region (192Q/R and 55L/M) polymorphisms that affect the levels and catalytic efficiency of the enzyme. respectively. In this study. we aimed to determine the importance of -107T/C. 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activity (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke