Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population

Demirdogen B. C., Demirkaya S., Turkanoglu A., Bek S., Arinc E., ADALI O.

CELL BIOCHEMISTRY AND FUNCTION, vol.27, no.8, pp.558-567, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1002/cbf.1607
  • Journal Name: CELL BIOCHEMISTRY AND FUNCTION
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.558-567
  • Keywords: genotype, paraoxonase, PON1, polymorphism, stroke, HUMAN-SERUM PARAOXONASE, DENSITY-LIPOPROTEIN OXIDATION, INTIMA-MEDIA THICKNESS, ARYLESTERASE, PROMOTER, PROTEIN, ASSOCIATION, CHOLESTEROL, HYDROLYSIS, PHENOTYPE
  • Middle East Technical University Affiliated: Yes

Abstract

Background Paraoxonase 1 (PON1) is protective against the development of atherosclerosis. a risk factor for ischemic stroke. PON1 gene has one promoter region (-107T/C) and two coding region (192Q/R and 55L/M) polymorphisms that affect the levels and catalytic efficiency of the enzyme. respectively. In this study. we aimed to determine the importance of -107T/C. 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activity (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke