Analysis of paraoxonase 1 (PON1) genetic polymorphisms and activities as risk factors for ischemic stroke in Turkish population


Demirdogen B. C. , Demirkaya S., Turkanoglu A., Bek S., Arinc E., ADALI O.

CELL BIOCHEMISTRY AND FUNCTION, vol.27, no.8, pp.558-567, 2009 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 8
  • Publication Date: 2009
  • Doi Number: 10.1002/cbf.1607
  • Title of Journal : CELL BIOCHEMISTRY AND FUNCTION
  • Page Numbers: pp.558-567
  • Keywords: genotype, paraoxonase, PON1, polymorphism, stroke, HUMAN-SERUM PARAOXONASE, LOW-DENSITY-LIPOPROTEIN, INTIMA-MEDIA THICKNESS, LIPID-PEROXIDATION, LDL OXIDATION, ARYLESTERASE, PROMOTER, PROTEIN, ATHEROSCLEROSIS, CHOLESTEROL

Abstract

Background Paraoxonase 1 (PON1) is protective against the development of atherosclerosis. a risk factor for ischemic stroke. PON1 gene has one promoter region (-107T/C) and two coding region (192Q/R and 55L/M) polymorphisms that affect the levels and catalytic efficiency of the enzyme. respectively. In this study. we aimed to determine the importance of -107T/C. 192Q/R and 55L/M polymorphisms of PON1 gene and three PON1 activity (diazoxonase, paraoxonase, arylesterase) as risk factors for ischemic stroke