This paper presents a multi objective mixed integer location/routing model that aims to minimize transportation cost and risks for large-scale hazardous waste management systems (HWMSs). Risks induced by hazardous wastes (HWs) on both public and the environment are addressed. For this purpose, a new environmental impact definition is proposed that considers the environmentally vulnerable elements including water bodies, agricultural areas, coastal regions and forestlands located within a certain bandwidth around transportation routes. The solution procedure yields to Pareto optimal curve for two conflicting objectives. The conceptual model developed prior to mathematical formulation addresses waste-to-technology compatibility and HW processing residues to assure applicability of the model to real-life HWMSs. The suggested model was used in a case study targeting HWMS in Turkey. Based on the proposed solution, it was possible to identify not only the transportation routes but also a set of information on HW handling facilities including the types, locations, capacities, and investment/operational cost. The HWMS of this study can be utilized both by public authorities and private sector investors for planning purposes. (C) 2016 Elsevier Ltd. All rights reserved.