Clean and efficient microwave-solvent-free conversion of homochiral amines, alpha-amino alcohols and alpha-amino acids to their chiral 2-substituted pyrrole derivatives

Aydogan F., Demir A.

TETRAHEDRON, vol.61, no.12, pp.3019-3023, 2005 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 12
  • Publication Date: 2005
  • Doi Number: 10.1016/j.tet.2005.01.120
  • Title of Journal : TETRAHEDRON
  • Page Numbers: pp.3019-3023
  • Keywords: pyrrole, microwave, silica gel, chloroenone, PHOTOOXYGENATION, ACYLATION, CHEMISTRY, SYSTEMS


Efficient synthesis of 1,2-disubstituted homochiral pyrroles has been achieved by a two-component coupling of chloroenones and amine compounds on the surface of silica gel without any solvent under microwave irradiation. (c) 2005 Elsevier Ltd. All rights reserved.