Highly sensitive and selective colorimetric probe for determination of L-cysteine in aqueous media based on Ag/Pd bimetallic nanoparticles


Farhadi K., Forough M. , Pourhossein A., Molaei R.

SENSORS AND ACTUATORS B-CHEMICAL, vol.202, pp.993-1001, 2014 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 202
  • Publication Date: 2014
  • Doi Number: 10.1016/j.snb.2014.05.129
  • Title of Journal : SENSORS AND ACTUATORS B-CHEMICAL
  • Page Numbers: pp.993-1001
  • Keywords: Colorimetric probe, Ag/Pd bimetallic nanoparticles, Cysteine, Determination, Aggregation, PERFORMANCE LIQUID-CHROMATOGRAPHY, LIGHT-SCATTERING TECHNIQUE, SURFACE-PLASMON RESONANCE, GOLD NANOPARTICLES, MASS-SPECTROMETRY, HOMOCYSTEINE, ACID, ELECTROPHORESIS, AMINOTHIOLS, GLUTATHIONE

Abstract

The interaction between Ag/Pd bimetallic nanoparticles and cysteine was introduced as a new and high potential colorimetric probe for the selective, sensitive and low-cost recognition and monitoring of cysteine in aqueous samples. In the presence of NaCl, cysteine was able to induce the aggregation of Ag/Pd bimetallic nanoparticles thereby resulting in a change in yellowish-brown color of the Ag/Pd colloid to green. The presence of 6.6 mM NaCl in the samples decreases the electrostatic repulsion and accelerates the aggregation of Ag/Pd nanoparticles. The sensitivity and selectivity of the proposed sensor toward the other amino acids were studied too. This simple assay was rapid (5 min) and highly sensitive (limit of detection (LOD) = 3.3 nM)), selective and it can be used for rapid monitoring of cysteine in real pharmaceutical formulation. (C) 2014 Elsevier B.V. All rights reserved.