Selective Recognition of Americium by Peptide-Based Reagents


Oezcubukcu S., Mandal K., Wegner S., Jensen M. P. , He C.

INORGANIC CHEMISTRY, vol.50, no.17, pp.7937-7939, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 17
  • Publication Date: 2011
  • Doi Number: 10.1021/ic201094e
  • Journal Name: INORGANIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.7937-7939
  • Middle East Technical University Affiliated: Yes

Abstract

The separation of lanthanides from minor actinides such as americium and curium is an important step during the recycling process in the treatment of nuclear waste. However, the similar chemistry and ionic size of lanthanide and actinide ions make the separation challenging. Here, we report that a peptide-based reagent can selectively bind trivalent actinides over trivalent lanthanides by means of introducing soft-donor atoms into a peptide known as a lanthanide-binding tag (LBT). Fluorescence spectroscopy has been used to measure the dissociation constant of each metal/peptide complex. A 10-fold selectivity was obtained for Am3+ over the similarly sized lanthanide cation, Nd3+, when the asparagine on the fifth position of a LBT was mutated to a cysteine and further functionalized by a pyridine moiety.