In additive manufacturing processes, the resulting products might have highly anisotropic granular morphologies due to the complex thermal history. The most commonly observed morphology is columnar structure. The resulting morphology of grains is accompanied by the orientation alignment leading to plastic anisotropy. It has been shown in a recent study through local crystal plasticity calculations that the morphology evolution does not influence the mechanical behavior without considering the texture evolution . However, the local frameworks do not consider the effect of the grain size which could be complicated due to high aspect ratio of the grains. This study aims to investigate the influence of the developed anisotropic grain structure on the macroscopic response through both local and non-local crystal plasticity frameworks to address the capacity of these models in capturing the realistic response. An additional subroutine is implemented (see ) into the crystal plasticity frameworks to obtain the slip resistance values at each material point based on grain geometries and misorientations. This allows the size dependent yielding of the crystals.