Interleukin-28 gene polymorphisms may contribute to HBsAg persistence and the development of HBeAg-negative chronic hepatitis B


Karatayli S. C. , Bozdayi M., Karatayli E., Ozturk T., Husseini A. A. , Albayrak R., ...Daha Fazla

LIVER INTERNATIONAL, cilt.35, ss.846-853, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 35 Konu: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/liv.12595
  • Dergi Adı: LIVER INTERNATIONAL
  • Sayfa Sayıları: ss.846-853

Özet

Background & AimsAim of this study was to investigate whether a potential association exists between several single nucleotide polymorphisms (SNPs) of the IL-28B gene (rs12979860, rs1188122, rs8099917, rs8105790, rs12980275) and HBsAg persistence. Further, a potential effect on the development of HBeAg-negative CHB vs. inactive HBsAg carrier state was assessed in a genotype D HBV cohort. A cohort of chronic HDV patients was also used to see if they behave differently compared to chronic HBV patients.