Synthesis of ferrocenyl pyrazoles by the reaction of (2-formyl-1-chlorovinyl)ferrocene with hydrazines

Zora M., Goermen M.

JOURNAL OF ORGANOMETALLIC CHEMISTRY, vol.692, no.22, pp.5026-5032, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 692 Issue: 22
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jorganchem.2007.07.029
  • Journal Name: JOURNAL OF ORGANOMETALLIC CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.5026-5032
  • Keywords: ferrocene, ferrocenyl, pyrazole, hydrazine, hydrazinium salt, hydrazide, propenal, density functional theory, B3LYP, ESTROGEN-RECEPTOR MODULATORS, ONE-POT SYNTHESIS, ACTIVITY IN-VITRO, REGIOSELECTIVE SYNTHESIS, ANTIMALARIAL ACTIVITY, ORGANOMETALLIC ANALOG, DIACETYLENIC KETONES, CRYSTAL-STRUCTURES, ACID, COMPLEXES
  • Middle East Technical University Affiliated: Yes

Abstract

Synthesis of ferrocenyl-substituted pyrazoles via the reaction between (2-formyl-1-chlorovinyl)ferrocene and hydrazine derivatives is described. Depending upon the substitution pattern of hydrazine, the reaction affords 1-alkyl/aryl-5-ferrocenylpyrazoles and/or 1-alkyl/ aryl-3-ferrocenylpyrazoles. The reaction appears to be general for a variety of hydrazine derivatives. (c) 2007 Elsevier B.V. All rights reserved.